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Participants noted that physiology research has generated many muscle biology advances, while bone research has strong roots in endocrinology.
“Bone studies are very interesting, because we know so little about its function, because we really don’t know what is the optimum duration of muscle mass maintenance. And I think it’s important in terms of what you can glean from bone. In terms of body composition, with the exception of young men, women are relatively lean in terms of how much body fat they have,” said Jorgensen. “But even then, our data shows that the optimal time to begin losing weight, when to start increasing muscle mass or lose muscle mass, when to start increasing fat mass, is based largely on bone composition and not muscle composition.”
The study included 14 healthy, sedentary adult men weighing between 80 and 110 pounds. Each participant underwent a combination of a 4-week study to assess muscle strength, an 8-week high-intensity interval training program, and a 8-week endurance training program to assess fat-free mass (FFM).
Participants met with the researchers after the fourth week and completed a questionnaire about their diets. They also reported their height and weight, and the frequency of any major medical illnesses, such as hypertension, diabetes, and a family history of kidney stones.
Muscle strength, FFM, and bone mineral density (BMD) were measured before and after the 2-wk study. Subjects consumed a nutrient-heavy diet (730-1,300 calories/d) with protein sources high in animal and fiber sources low in animal products, including whole milk, low-fat cheese, and low-fat yogurt (5, 7). In addition, participants consumed an approximately 400 mL protein drink with daily doses of vitamin B12 (500-1,050 mcg/d) and calcium (1,000-1,500 mg/d). Each participant received one of two identical-sized breakfast or lunch meals, along with protein supplements and supplements for B12, calcium, and Biotin. Fasting blood samples were taken before and at the 2-wk end of the study, and muscle and fat bioavailability was assayed after 1, 2, 4, and 8 wks.
Muscle strength peaked after the 16-wk study but remained unchanged for the 18-wk study (Figure 1). FFM increased by 1.7 kg, or 3-3.5% of baseline, during the 16-wk study and remained unchanged for the 18-wk study (Figure 1). A mean BMD change of 2.9% and a mean
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